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- Interleukin 7 (IL-7) selectively promotes mouse and human IL-17–producing ?? cells
Purified anti-human IL-7 Antibody
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The aim of the study was to characterize the expression of IL-7 and IL-7R in rheumatoid arthritis RA synovial tissue and to examine their regulation and pathogenic role in macrophages, endothelial cells and RA synovial tissue fibroblasts. Consistently, expression of IL-7 and its receptor were significantly elevated in RA synovial fluid and peripheral blood macrophages as well as RA fibroblasts compared to normal cells. IL-7 also mediated RA pathogenesis by inducing production of potent proangiogenic factors from macrophages and endothelial cells. It has been shown that rheumatoid arthritis RA patients have elevated levels of circulating IL-7 compared to normal individuals 5 , 6. Additionally, an increased concentration of IL-7 has been detected in RA compared to osteoarthritis OA synovial fluid 7 , 8.
Recovery of thymopoiesis is critical for immune reconstitution after HSCT. IL-7 and SCF are two major thymotropic cytokines. We investigated whether the kinetics of circulating levels of these cytokines might provide insight into the prolonged immunodeficiency after double umbilical cord blood transplantation dUCBT in adults. SCF showed a less than 2-fold increase and more protracted elevation than IL This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: The authors have declared that no competing interests exist.
IL-7 is a potent lymphoid cell growth factor which promotes the proliferation of pre-B cells, thymocytes, T cell progenitors, and mature T cells. IL-7 can induce upregulation of proinflammatory cytokines in myeloid cells. IL-7 is expressed by stromal cells. It is recommended that the reagent be titrated for optimal performance for each application. Fitzgerald K, et al.
Author contributions: M. Pennington, and A. Pang, and S. Pang, S. They likewise underpin immunopathology in widely used models of inflammatory disease 10 ,
Il 7 e l'8 "7 and 8" is a Italian comedy film written and directed by Giambattista Avellino and by Ficarra e Picone. - The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor HGF form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor.
Interleukin 7 IL-7 is a protein  that in humans is encoded by the IL7 gene. IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. It is also produced by keratinocytes ,  dendritic cells ,  hepatocytes ,  neurons , and epithelial cells ,  but is not produced by normal lymphocytes. The three-dimensional structure of IL-7 in complex with the ectodomain of IL7R has been determined using X-ray diffraction. IL-7 stimulates the differentiation of multipotent pluripotent hematopoietic stem cells into lymphoid progenitor cells as opposed to myeloid progenitor cells where differentiation is stimulated by IL IL-7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor HGF form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor.
Here, the effect of transient hyperexpression of IL-7 was investigated on immune regulation and allograft rejection under immunosuppression. As expected, Dexamethasone and Doxycycline treatment prolonged graft median survival as compared to the untreated control group in this transplantation mouse model. Altogether, the findings show that transient elevations of IL-7 can impair immune regulation and lead to graft loss also under immune suppression. IL-7 deficiency results in a severe block in B cell development at the transition from Pro-B to Pre-B cells in mice 1 , and studies suggest that IL-7 is also critical for human B cell development 2. IL-7 is also an essential modulator of T cell homeostasis. In the steady state, the immune system relies on low concentrations of IL-7 to regulate T cell homeostasis and preserve T cell repertoire diversity 3 , 4.
Interleukin 7 (IL-7) selectively promotes mouse and human IL-17–producing ?? cells